crizotinib improves levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Dose reduction may be needed for coadministered prescription drugs which can be predominantly metabolized by CYP3A.iloperidone raises amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution